PNI Renal. Los beneficios de la Melatonina

¿Sabias que cuando duermes tus riñones tienen la capacidad de regenerarse?(1)

1-Melatonin in chronic kidney disease: a promising chronotherapy targeting the intrarenal renin–angiotensin system. Hypertension research,  42,  pages 920–923(2019).

 

¿A través de que mecanismos puede la melatonina promover la regeneración del riñón?

• Disminuye la hipertensión(2,3,4)

2-Altered circadian timing system-mediated non-dipping pattern of blood pressure and associated cardiovascular disorders in metabolic and kidney diseases. Int J Mol Sci. 2018;19:E400. pii

3-Effect of Melatonin on the Renin-Angiotensin-Aldosterone System in l-NAME-Induced Hypertension. Molecules. 2018;23:E265. pii

4-Altered circadian timing system-mediated non-dipping pattern of blood pressure and associated cardiovascular disorders in metabolic and kidney diseases. Int J Mol Sci. 2018;19:E400. pii

 

• Suprime mediadores inflamatorios y protege de la lesion inflamatoria y reduce el estrés oxidativo(5)

(5)Melatonin and renal protection: novel perspectives from animal experiments and human studies (review). Curr Pharm Des. 2015;21:936–49.

 

• Regula el ciclo circadiano del sueño-vigilia(6)

(6)The role of Melatonin Treatment in chronic kidney disease. Front Biosci. 2012;17:2644–56.

• Mejora la calidad del sueño (reparador)(7)

(7)Melatonin and renal protection: novel perspectives from animal experiments and human studies (review). Curr Pharm Des. 2015;21:936–49.

 

• Relajación del Sistema RAS (Renina-Angiotensina-Aldosterona)(8)

(8)Evaluation of continuous positive airway pressure therapy on renin–angiotensin system activity in obstructive sleep apnea. Am J Respir Crit Care Med. 2014;190:572–80.

 

• Mejora el aporte de oxigeno nocturno al riñón (9)

(9)Evaluation of continuous positive airway pressure therapy on renin–angiotensin system activity in obstructive sleep apnea. Am J Respir Crit Care Med. 2014;190:572–80.

• Disminuye la retención de sodio por la noche (10)

(10)Intrarenal renin-angiotensin system in regulation of glomerular function. Curr Opin Nephrol Hypertens. 2014;23:38–45.

• Activación de la regeneración a partir de celulas madre renales (11)

(11)Melatonin-stimulated exosomes enhance the regenerative potential of chronic kidney disease-derived mesenchymal stem/stromal cells via cellular prion proteins Journal Pineal Research,  2020 Apr;68(3):e12632.